• Instructor: Tom Steven
  • Students: 2344
  • Duration: 5 weeks
  • Introduction to genomics
  • Gene prediction methods and tools.
  • Basic structures of nucleotides.
  • Introduction to biological databases – primary, secondary and composite databases
  • Data storage and formats. NCBI
  • Nucleic acid databases (GenBank, EMBL, DDBJ)
  • Protein databases (PIR, Swiss-Prot TrEMBL, PDB)
  • Metabolic pathway database – KEGG.
  • Small molecule databases (PubChem, Drug Bank, ZINC).
  • Protein domains
  • Conserved domains and repeats analysis.
  • Alignment – local and global alignment,
  • Pair-wise and multiple sequence alignments.
  • Alignment algorithms
  • BLAST 
  • CLUSTALW
  • Amino acid substitution matrices (PAM and BLOSUM).
  • Multiple sequence alignments
  • Construction of phylogenetic tree and dendrograms.
  • Amino acid structures
  •  Levels of protein organization – Primary, Secondary, Tertiary & Quaternary structures
  • Protein secondary structure prediction
  • 3D structure building using homology modeling
  •  Ramachandran Plot
  • Protein preparation
  • Ligand preparation
  •  Grid generation
  •  Docking Algorithms
  • Docking Analysis
  • Virtual Screening

Curriculum is empty

Price

Free
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